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Ex-vivo screening platform to identify tumor-specific therapies

ABSTRACT: We report the generation of a preclinical IBC patient-derived xenograft (PDX)-derived ex vivo tumor tissue model and show that it closely replicates the tissue architecture of the original PDX tumor harvested from mice and show that its genetic signature highly correlates with that of the original tumor. We used microarrays to evaluate the robustness and reproducibility of the method used to generate the ex vivo tumor tissue model and confirm its ability to recapitulate the essential features of the original tumor.

ORGANISM(S): Homo sapiens

PROVIDER: GSE106685 | GEO | 2018/04/07

REPOSITORIES: GEO

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