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Divergent principles specifying inflammatory versus antiviral transcriptional programs in dendritic cells [ATAC-seq]

ABSTRACT: Stimulus-specific gene expression programs are enabled by enhancers, on which stimulus-regulated transcription factors (SRTFs) can land in a cell type- and stimulus-dependent manner. In this study, we identified the key features of enhancers that mediate differential responses to Toll-like receptor (TLR)-stimulation. We characterized the TLR3- and TLR9-induced programs and enhancers in CD8+ dendritic cells.The relevance of these features has been confirmed via machine learning application and by mapping SRTF-binding.

ORGANISM(S): Mus musculus

PROVIDER: GSE106743 | GEO | 2019/07/31

REPOSITORIES: GEO

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