Transcriptomics

Dataset Information

0

Hair follicle stem cells sense niche integrity and recruit immune cells to contain barrier breaches


ABSTRACT: We demonstrated that hair follicle stem cells (HFSCs) are able to sense the integrity of their epithelial niche. By ablating a core cell junction component E-cadherin (encoded by Cdh1), the epithelial niche no longer maintains proper barrier function, leading to microbial infiltration through the hair follicle. The surrounding HFSCs respond by increasing its expression of immune associated genes and recruiting immune cells to their niche so as to cope with compromised tissue function.

ORGANISM(S): Mus musculus

PROVIDER: GSE106767 | GEO | 2018/12/28

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2012-01-04 | E-GEOD-33471 | biostudies-arrayexpress
2016-02-16 | E-GEOD-77256 | biostudies-arrayexpress
2013-12-03 | GSE48878 | GEO
2019-12-31 | GSE124901 | GEO
2020-07-15 | GSE130240 | GEO
2022-06-30 | GSE201445 | GEO
2023-02-28 | GSE223723 | GEO
2014-01-28 | E-GEOD-54424 | biostudies-arrayexpress
2021-05-07 | PXD018352 | Pride
| PRJNA417941 | ENA