Transcriptomics

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Expression data from brain tissue of Rattus norvegicus treated with D-Serine


ABSTRACT: d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. Affymetrix microarray technology was used to determine differential gene expression resulting from D-Serine exposure. Keywords: Dose course

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE10748 | GEO | 2008/03/08

SECONDARY ACCESSION(S): PRJNA107529

REPOSITORIES: GEO

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