Expression data from brain tissue of Rattus norvegicus treated with D-Serine
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Molly Davidson
PROVIDER: E-GEOD-10748 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
D-Serine exposure resulted in gene expression changes implicated in neurodegenerative disorders and neuronal dysfunction in male Fischer 344 rats.
Davidson Molly E ME Kerepesi Laura A LA Soto Armando A Chan Victor T VT
Archives of toxicology 20090211 8
D-Serine, an endogenous amino acid, is involved in many physiological processes through its interaction with the glycine binding site of the N-methyl-D-aspartate (NMDA) receptor. It has important roles in development, learning, and cell death signaling. Recent evidence suggests that decreased function of the NMDA receptor is related to the etiology of schizophrenia, and the use of D-serine as add-on therapy is beneficial in alleviating the symptoms of treatment-refractory schizophrenia. The NMDA ...[more]
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