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Single cell transcriptome datasets of murine B cell commitment

ABSTRACT: To identify the “time-lapse” TF networks during B lineage commitment, we established multipotent progenitors harboring a tamoxifen-inducible form of Id3, an in vitro system where virtually all cells became B cells within 6 days by simply withdrawing 4-OHT. In this study, single cell transcriptomic analysis at pre- and post-commitment was performed using the culture system. In addition, we also performed single cell RNA-seq analysis of B cell precursor populations (LMPP, CLP and pro-B cells) in murine bone marrow.

ORGANISM(S): Mus musculus

PROVIDER: GSE107527 | GEO | 2018/02/20

REPOSITORIES: GEO

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