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DNA methylation profile of Tasmanian Devil facial tumor biopsies and matched healthy skin and spleen samples, as well as additional nerve tissue, and strain 1 tumor cell line.

ABSTRACT: Purpose: Depict the landscape of epigenetic regulation in Tasmanian devil facial tumor biopsies. Differential analysis of healthy versus tumor biopsies highlighted 166 candidate genes with different DNA methylation levels in their promoters, which included the tumor-specific hypermethylated promoters of Estrogen Receptor 1 (ESR1) and the transcription factor GATA3.

OTHER RELATED OMICS DATASETS IN: PXD009283

ORGANISM(S): Sarcophilus harrisii

PROVIDER: GSE108160 | GEO | 2019/01/14

REPOSITORIES: GEO

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