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Passage of transmissible cancers in the Tasmanian devil is due to a dominant, shared peptide motif and a limited repertoire of MHC-I allotypes

ABSTRACT: Transmissible cancers are spread via the passage of malignant cells. The survival of the Tasmanian devil, the largest marsupial carnivore, is threatened by two independent transmissible cancers, devil facial tumour (DFT) 1 and devil facial tumour 2 (DFT2). To aid the development of a peptide vaccine and to interrogate how histocompatibility barriers can be overcome, we analysed the peptides bound to Major Histocompatibility Complex class I molecules from the Tasmanian devil and its transmissible tumours.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Sarcophilus Harrisii

TISSUE(S): Cell Culture

SUBMITTER: Sri Ramarathinam

LAB HEAD: Anthony Wayne Purcell

PROVIDER: PXD020614 | Pride | 2021-02-08

REPOSITORIES: pride

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			Action	DRS
	20170929_sr_DFT1_mhc_rep1_A1.raw	Raw
	20170929_sr_DFT1_mhc_rep1_A10.raw	Raw
	20170929_sr_DFT1_mhc_rep1_A2.raw	Raw
	20170929_sr_DFT1_mhc_rep1_A3.raw	Raw
	20170929_sr_DFT1_mhc_rep1_A4.raw	Raw

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