Co-Culture of CD8+ T cells and Breast Cancer Cells

ABSTRACT: Targeting of tumor immune escape mechanisms holds enormous therapeutic potential. Still, most patients progress under immune checkpoint blockade and some even become hyper-progressors. To investigate how cancer cells respond to activated but ineffective T cells, we challenged peptide-loaded MCF-7 breast cancer cells with antigen-specific CD8+ T cells in which Perforin had been destroyed by pre-treatment with Concanamycin A.

ORGANISM(S): Homo sapiens

PROVIDER: GSE108236 | GEO | 2019/11/25

REPOSITORIES: GEO