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Transcriptional profiling of growing and senescent WT and IL-1R-depleted IMR90 cells

ABSTRACT: Senescent cells no longer divide, but remain metabolically active and secrete an array of cytokines, growth factors, and proteases termed the senescence-associated secretory phenotype (SASP). Previous studies have indicated that the SASP factor IL-1α may be an upstream regular of the SASP. We show here that knockdown of the IL-1α receptor IL-1R results in a sizable reduction of SASP expression late in senescence induction. Our results suggest that targeting the IL-1 signaling pathway is a reliable method to dissociate the SASP from cell-cycle exit.

ORGANISM(S): Homo sapiens

PROVIDER: GSE108278 | GEO | 2019/04/16

REPOSITORIES: GEO

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