Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single cell expression profiling of murine p53-/- shPU.1 AML cells following PU.1 restoration

ABSTRACT: We have utilized advanced RNAi technology to dynamically restore endogenous PU.1 expression in p53-deficient AML cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE109100 | GEO | 2019/05/13

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

PU.1 ChIP-seq in p53-/- shPU.1 AML cells following acute PU.1 restoration

Project description:We have utilized advanced RNAi technology to dynamically restore endogenous PU.1 expression and perform PU.1 ChIP-seq in p53-deficient shPU.1 AML cells in vivo. This causes rapid cell cycle shutdown and myeloid differentiation. PU.1 restoration results in regression and clearance and prolongs survival.

2019-05-13 | GSE76933 | GEO

Expression profiling of murine monosomal karyotype p53-/- shPU.1 AML cells following gradual PU.1 restoration

Project description:We have utilized advanced RNAi technology to dynamically restore endogenous PU.1 expression in p53-deficient AML cells. This causes rapid cell cycle shutdown and myeloid differentiation. PU.1 restoration results in regression and clearance and prolongs survival.

2019-05-13 | GSE76875 | GEO

Expression profiling of murine cytogenetic normal p53-/- shPU.1 AML cells following gradual PU.1 restoration

Project description:We have utilized advanced RNAi technology to dynamically restore endogenous PU.1 expression in p53-deficient AML cells . This causes rapid cell cycle shutdown and myeloid differentiation. PU.1 restoration results in regression and clearance and prolongs survival.

2019-05-13 | GSE76874 | GEO

Expression profiling of p53-/- shPU.1 AML cells single cell clones

Project description:We have utilized advanced RNAi technology to dynamically restore endogenous PU.1 expression in p53-deficient shPU.1 AML single cell clones in vitro. This causes rapid cell cycle shutdown and reversible myeloid differentiation.

2019-05-13 | GSE76879 | GEO

PU.1 ChIP-seq time course in mouse acute myeloid leukemia cells upon PU.1 restoration and knockdown

Project description:We have utilized advanced RNAi technology to dynamically restore and subsequently knock down endogenous PU.1 expression in p53-deficient AML cells, which respectively causes differentiation and de-differentiation

2019-05-13 | GSE108945 | GEO

Transcriptome time course of mouse acute myeloid leukemia cells upon PU.1 restoration and knockdown

2019-05-13 | GSE108946 | GEO

ATAC-seq time course in mouse acute myeloid leukemia cells upon PU.1 restoration and knockdown

2019-05-13 | GSE108944 | GEO

Single cell expression profiling of murine p53-/- shPU.1 AML cells following PU.1 restoration

Project description:Single cell expression profiling of murine p53-/- shPU.1 AML cells following PU.1 restoration

| PRJNA429645 | ENA

Expression profiling of mouse T-ALL (Vav-tTA;TRE-GFP-shIkaros primary leukemia ALL211) cells following Ikaros restoration

Project description:To examine Ikaros tumor suppressor mechanisms, we have utilized inducible RNAi to dynamically restore endogenous Ikaros expression in T-ALL driven by its knockdown. This causes rapid transcriptional repression of Notch1 and associated targets including Myc, even in leukemias harboring spontaneous activating Notch1 mutations (producing aberrant ICN1) similar to those found in 60% of human T-ALL. Ikaros restoration results in sustained regression of Notch1-wild type leukemias while endogenous or engineered ICN1 expression promotes rapid disease relapse, indicating that ICN1 functionally antagonizes Ikaros in T-ALL. RNA-seq was performed on T-ALL (Vav-tTA;TRE-GFP-shIkaros primary leukemia ALL211) cells isolated from two untreated and two 3-day Dox-treated mice.

2015-02-02 | E-GEOD-64899 | biostudies-arrayexpress

Expression profiling of mouse T-ALL (Vav-tTA;TRE-GFP-shIkaros primary leukemia ALL211) cells following Ikaros restoration

2015-02-02 | GSE64899 | GEO