Transcriptomics

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Expression profiling of murine monosomal karyotype p53-/- shPU.1 AML cells following gradual PU.1 restoration


ABSTRACT: We have utilized advanced RNAi technology to dynamically restore endogenous PU.1 expression in p53-deficient AML cells. This causes rapid cell cycle shutdown and myeloid differentiation. PU.1 restoration results in regression and clearance and prolongs survival.

ORGANISM(S): Mus musculus

PROVIDER: GSE76875 | GEO | 2019/05/13

REPOSITORIES: GEO

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