Expression profiling of murine monosomal karyotype p53-/- shPU.1 AML cells following gradual PU.1 restoration
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ABSTRACT: We have utilized advanced RNAi technology to dynamically restore endogenous PU.1 expression in p53-deficient AML cells. This causes rapid cell cycle shutdown and myeloid differentiation. PU.1 restoration results in regression and clearance and prolongs survival.
ORGANISM(S): Mus musculus
PROVIDER: GSE76875 | GEO | 2019/05/13
REPOSITORIES: GEO
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