Transcriptomics

Dataset Information

0

The Effect of TLR2 Activation on Transcriptome of IFN-induced Microglia


ABSTRACT: In murine glioma models, TLR2 is selectively upregulated in glioma-associated microglia. We found that TLR2 activation led to down-regulation of MHC-II in microglia. Therefore, we examined the effect of TLR2 activation on IFN-gamma-induced microglial transcriptome by in vitro culture of murine adult microglia. In the study, we confirmed that TLR2 activation led to Ciita shutdown and inhibition of MHC-II related genes, which also revealed the role of TLR2 in inducing APC disability and tumor immune escape. In addition, this work can be used to reveal the transcriptional characteristics of murine microglia during IFN-gamma and TLR2 activation.

ORGANISM(S): Mus musculus

PROVIDER: GSE109297 | GEO | 2018/09/25

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2022-12-10 | GSE218132 | GEO
2024-09-02 | BIOMD0000000808 | BioModels
2012-01-25 | E-GEOD-28499 | biostudies-arrayexpress
2012-12-13 | E-GEOD-24155 | biostudies-arrayexpress
2017-08-09 | PXD006558 | Pride
| PRJNA99625 | ENA
2012-01-25 | GSE28499 | GEO
| PRJNA430373 | ENA
2016-07-26 | E-GEOD-84772 | biostudies-arrayexpress
2012-12-13 | GSE24155 | GEO