Dataset Information

Kronik2008 - Improving alloreactive CTL immunotherapy for malignant gliomas using a simulation model of their interactive dynamics

ABSTRACT: This mathematical model describes interactions between glioma tumors and the immune system that may occur following direct intra-tumoral administration of ex-vivo activated alloreactive cytotoxic-T-lymphocytes (aCTLs) as part of adoptive immunotherapy. The model includes descriptions of aCTL, neoplastic cells, MHC class I and II molecules, TGF-beta and IFN-gamma.

SUBMITTER: Johannes Meyer

PROVIDER: BIOMD0000000808 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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Dataset's files

Source:

			Action	DRS
	BIOMD0000000808?filename=Kronik2008-biopax2.owl	Owl
	BIOMD0000000808?filename=Kronik2008-biopax3.owl	Owl
	BIOMD0000000808?filename=Kronik2008-matlab.m	Other
	BIOMD0000000808?filename=Kronik2008-octave.m	Other
	BIOMD0000000808?filename=Kronik2008.cps	Other

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Publications

Predicting outcomes of prostate cancer immunotherapy by personalized mathematical models.

Kronik Natalie N Kogan Yuri Y Elishmereni Moran M Halevi-Tobias Karin K Vuk-Pavlović Stanimir S Agur Zvia Z

PloS one 20101208 12

<h4>Background</h4>Therapeutic vaccination against disseminated prostate cancer (PCa) is partially effective in some PCa patients. We hypothesized that the efficacy of treatment will be enhanced by individualized vaccination regimens tailored by simple mathematical models.<h4>Methodology/principal findings</h4>We developed a general mathematical model encompassing the basic interactions of a vaccine, immune system and PCa cells, and validated it by the results of a clinical trial testing an allo ...[more]

PMID: 21151630

Publication: 1/2

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