Methylation profiling

Dataset Information

0

Alzheimer's disease DNA (hydroxy) methylome in the brain: OXT methylation as a preclinical marker.


ABSTRACT: The present study investigated the DNA methylome and hydroxymethylome, as well as unmodified cytosine in relation to Alzheimer’s disease (AD). We identified epigenetic differences between AD patients and age-matched controls in the middle temporal gyrus, in genomic regions associated with genes such as OXT, ACSL1, RHBDF2, C3, and MIR9-3HG. Interestingly, we found that OXT methylation in the blood of aged, non-demented individuals is also associated with conversion to AD dementia. The current GEO records concerns the middle temporal gyrus (ox)BS-processed Illumina 450K dataset of this study.

ORGANISM(S): Homo sapiens

PROVIDER: GSE109627 | GEO | 2019/12/09

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2019-12-09 | GSE109887 | GEO
2007-12-05 | GSE9770 | GEO
2015-12-18 | GSE76105 | GEO
2015-12-18 | E-GEOD-76105 | biostudies-arrayexpress
2017-04-27 | GSE57152 | GEO
2017-08-01 | GSE70424 | GEO
2021-06-01 | GSE163877 | GEO
2019-04-23 | GSE122063 | GEO
2016-09-29 | PXD004499 | Pride
2019-06-19 | GSE132903 | GEO