Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA Expression (log2) in Marrow Subsets fromTwo Cebpa-Enhancer/Promoter-hCD4 Mice

ABSTRACT: To gain insight into regulation of B cell development by C/EBPa, we compared gene expression in hCD4- vs hCD4+ subsets of preproB and proB cells from Cebpa-Enh/prom-hCD4 mice, with preB cells and hCD4+ GMP also analyzed for comparison.

ORGANISM(S): Mus musculus

PROVIDER: GSE110034 | GEO | 2018/12/25

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

RNA expression analysis of lineage-negative marrow progenitors after Cebpa knockdown.

Project description:Analysis of global RNA expression of Cebpa knockdown lineage-negative marrow cells reveals known and potentially novel C/EBPa targets.

2014-03-11 | GSE55760 | GEO

RNA expression analysis of lineage-negative marrow progenitors after Cebpa knockdown.

Project description:Analysis of global RNA expression of Cebpa knockdown lineage-negative marrow cells reveals known and potentially novel C/EBPa targets. Total RNA from lineage-negative marrow progenitors transduced with vector or Cebpa shRNA and cultured under myeloid differentiation condition for 2 days were compared.

2014-03-11 | E-GEOD-55760 | biostudies-arrayexpress

The role of Erg in B cell development (ATAC-Seq)

Project description:ATAC-seq of pre-proB, proB and preB populations from Ergfl/fl bone marrow, pre-proB cell population from Rag1CreT/+;ErgΔ/Δ bone marrow, and pre-proB, proB and preB populations from from Rag1CreT/+;ErgΔ/Δ;IgHVH10tar bone marrow.

2020-04-14 | GSE132852 | GEO

Cebpa regulates gene transcription in basophils

Project description:To investigate the mechanisms by which C/EBPa drives basophil differentiation and maintains basophil identity, we examined whether or not C/EBPa promotes basophil molecular programming and simultaneously represses mast cell molecular programming. We performed genome-wide gene expression profiling on basophils and mast cells and found that 6798 genes were shared by mast cells and basophils; 2033 genes were expressed 2-10 (log2 1-3.3)-fold higher in basophils (differentially expressed in basophils); and 413 genes were expressed greater than 10 (log2 3.3)-fold in basophils (highly expressed in basophils). On the other hand, we found 569 genes were expressed 2-10 (log2 -1 to -3.3) fold higher in mast cells and 171 genes were highly expressed in mast cells [greater than 10 fold (log2 -3.3)]. We treated purified basophils prepared from Cebpaf/f RosaYFP/creER mice and Cebpa+/+ RosaYFP/creER control mice with or without 4HT treatment for five days. Gene expression in the treated basophils was analyzed using microarray analysis. Overall, deletion of C/EBPa in basophils resulted in a reduction of mRNA expression for 248 genes and led to an increase in mRNA expression for 255 genes. The majority of the C/EBPa-regulated genes were either differentially or highly expressed in basophils or mast cells. In this study, we compared gene expression in basophils and mast cell and identified genes which specifically expressed in basophils and mast cells. By using Cebpa conditional knock out mice, we identified Cebpa regulated genes in basophils.

2013-04-01 | E-GEOD-41596 | biostudies-arrayexpress

Infection exposure promotes ETV6-RUNX1 precursor B cell leukemia revealing secondary genomic alterations in histone modification genes

Project description:We used microarrays to investigate gene expression changes in ETV6/RUNX1 proB and preB cells Bone marrow proB and preB cells of four ETV6/RUNX1 mice compared with bone marrow proB and preB cells of three WT mice and three Pax5+/- mice.

2015-07-03 | E-GEOD-70492 | biostudies-arrayexpress

RNA Expression (log2) in preproB Cells from Two Cebpa +37 kb Enhancer(f/f) or Cebpa +37 kb Enhancer(f/f);Mx1-Cre Mice Exposed to pIpC 5 Weeks Earlier

Project description:To gain insight into regulation of B cell development by C/EBPa, we compared gene expression in preproB cells with or without the +37 kb Cebpa enhancer.

2018-12-25 | GSE110029 | GEO

The role of Erg in B cell development (RNA-Seq)

Project description:RNA-seq of pre-proB, proB and preB populations from Ergfl/fl bone marrow, pre-proB cell population from Rag1CreT/+;ErgΔ/Δ bone marrow

2020-04-14 | GSE132854 | GEO

RNA Expression (log2) in Marrow Subsets fromTwo Cebpa-Enhancer/Promoter-hCD4 Mice

Project description:RNA Expression (log2) in Marrow Subsets fromTwo Cebpa-Enhancer/Promoter-hCD4 Mice

| PRJNA432596 | ENA

Cebpa regulates gene transcription in basophils

2013-04-01 | GSE41596 | GEO

Infection exposure promotes ETV6-RUNX1 precursor B cell leukemia revealing secondary genomic alterations in histone modification genes

Project description:We used microarrays to investigate gene expression changes in ETV6/RUNX1 proB and preB cells

2015-07-03 | GSE70492 | GEO