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RNA-seq analysis of RALD iPSCs after in vitro differentiation

ABSTRACT: We investigated roles of KRAS on stemness maintenance and differentiation propensity in the context of induced pluripotent stem cells (iPSCs) using isogenic KRAS mutant (G13C/WT) and wild-type (WT/WT) iPSCs from the same RAS-associated autoimmune lymphoproliferative syndrome-like disease (RALD) patients. RNA-seq analysis was conducted to compare gene expression profiles of WT/WT and G13C/WT iPS cells after in vitro differentiation. We found some differences of gene expression profiles regarding stemness and linage markers in the two genotypes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE111345 | GEO | 2018/04/01

REPOSITORIES: GEO

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