Transcriptomics

Dataset Information

0

Hematopoietic Stem Cell Heterogeneity in JAK2 V617F+ Essential Thrombocythemia


ABSTRACT: In this study, we explored the transcriptome of hematopoietic stem cells (HSCs) and megakaryocyte-erythroid progenitors (MEPs) in JAK2 V617F+ PV and ET and found that distinctive gene expression patterns within MPN subtypes begin at the HSC stage. HSCs from ET exhibited prominent megakaryocyte (Mk)-lineage priming. The differentially expressed genes (DEGs) indicated that cellular processes and signaling pathways in HSCs and MEPs from healthy donors (HDs), PV and ET patients are differentially modulated

ORGANISM(S): Homo sapiens

PROVIDER: GSE111410 | GEO | 2021/02/22

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2023-04-12 | GSE168368 | GEO
2024-03-29 | GSE255253 | GEO
2024-03-29 | GSE225918 | GEO
| PRJNA436952 | ENA
2018-03-01 | GSE103238 | GEO
2018-03-01 | GSE103237 | GEO
2011-01-22 | E-GEOD-26775 | biostudies-arrayexpress
| S-EPMC3145111 | biostudies-literature
| PRJNA938038 | ENA
2011-01-10 | GSE19901 | GEO