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Multi-omic analyses reveal minimal impact of the CRISPR-Cas9 nuclease on the host

ABSTRACT: Transcriptomics strategies were applied to explore the cellular feedback after incorporating the Cas9. HEK293T cell lysates were collected after 24h transfected with PX330-GFP-cas9-6T, PX330-GFP-cas9-luciferase, PX330-GFP-noCas9-6T, PX330-GFP-noCas9-luciferase. RNA-seq data were generated from deep sequence. We found the impact caused by Cas9 is very minor

ORGANISM(S): Homo sapiens

PROVIDER: GSE112076 | GEO | 2021/03/20

REPOSITORIES: GEO

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