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Transcription profiling of human stable end-stage renal disease patients reveals nocturnal hemodialysis improves erythropoietin responsiveness

ABSTRACT: Nocturnal home hemodialysis (NHD) [5 – 6 times a week, 6-8 hours per session] augments uremia clearance and is associated with an increase in hemoglobin level. We have used microarray to have a global image of the changes at the gene expression. Experiment Overall Design: Sixteen stable end-stage renal disease patients (age: 47 ± 2 years; 9M) [mean ± SEM] were studied. Total RNA (TRNA) was isolated from whole blood before and after 3 months of established NHD. Gene expression before and after NHD was acquired through hybridizations on Human HG-U133_PLUS2 GeneChip and genes with differential gene expression were identified.

ORGANISM(S): Homo sapiens

SUBMITTER: Sara Arab 

PROVIDER: E-GEOD-11227 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Nocturnal hemodialysis improves erythropoietin responsiveness and growth of hematopoietic stem cells.

Chan Christopher T CT   Liu Peter P PP   Arab Sara S   Jamal Nazir N   Messner Hans A HA  

Journal of the American Society of Nephrology : JASN 20081217 3

Nocturnal home hemodialysis (NHD) is associated with an increase in hemoglobin level. We hypothesized that NHD enhances the removal of toxins of hematopoietic progenitor cells (HPCs), thereby improving HPC growth and function. Among 16 patients with ESRD, 2 mo of NHD nearly doubled Kt/V per session and significantly lowered both parathyroid hormone levels and serum phosphate concentration. In addition, treatment with NHD improved hemoglobin levels from 113 +/- 3 to 125 +/- 4 g/L (P = 0.03) witho  ...[more]

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