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SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE112835 | GEO | 2019/05/01

REPOSITORIES: GEO

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SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development [Bisulfite-seq]

Project description:The oocyte epigenome plays critical roles in mammalian gametogenesis and embryogenesis. Yet, how it is established remains elusive. Here, we report that histone-lysine N-methyltransferase SETD2, an H3K36me3 methyltransferase, is a crucial regulator of the mouse oocyte epigenome. Deficiency in Setd2 leads to extensive alterations of the oocyte epigenome, including the loss of H3K36me3, failure in establishing the correct DNA methylome, invasion of H3K4me3 and H3K27me3 into former H3K36me3 territories and aberrant acquisition of H3K4me3 at imprinting control regions instead of DNA methylation. Importantly, maternal depletion of SETD2 results in oocyte maturation defects and subsequent one-cell arrest after fertilization. The preimplantation arrest is mainly due to a maternal cytosolic defect, since it can be largely rescued by normal oocyte cytosol. However, chromatin defects, including aberrant imprinting, persist in these embryos, leading to embryonic lethality after implantation. Thus, these data identify SETD2 as a crucial player in establishing the maternal epigenome that in turn controls embryonic development.

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SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development [RNA-seq]

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SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development [ChIP-seq]

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SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development

Project description:SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development

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SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development [RNA-seq]

Project description:SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development [RNA-seq]

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SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development [Bisulfite-seq]

Project description:SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development [Bisulfite-seq]

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SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development [ChIP-seq]

Project description:SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development [ChIP-seq]

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Histone Lysine Methyltransferase SETD2 Regulates Coronary Vascular Development in Embryonic Mouse Hearts.

Project description:Congenital heart defects are the most common birth defect and have a clear genetic component, yet genomic structural variations or gene mutations account for only a third of the cases. Epigenomic dynamics during human heart organogenesis thus may play a critical role in regulating heart development. However, it is unclear how histone mark H3K36me3 acts on heart development. Here we report that histone-lysine N-methyltransferase SETD2, an H3K36me3 methyltransferase, is a crucial regulator of the mouse heart epigenome. Setd2 is highly expressed in embryonic stages and accounts for a predominate role of H3K36me3 in the heart. Loss of Setd2 in cardiac progenitors results in obvious coronary vascular defects and ventricular non-compaction, leading to fetus lethality in mid-gestation, without affecting peripheral blood vessel, yolk sac, and placenta formation. Furthermore, deletion of Setd2 dramatically decreased H3K36me3 level and impacted the transcriptional landscape of key cardiac-related genes, including Rspo3 and Flrt2. Taken together, our results strongly suggest that SETD2 plays a primary role in H3K36me3 and is critical for coronary vascular formation and heart development in mice.

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Maternal Vitamin C regulates DNA demethylation and development of the mouse embryonic germline

Project description:This SuperSeries is composed of the SubSeries listed below.

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H3K36 methyltransferase SETD2 regulates NHEJ during lymphoid and neural development

Project description:This SuperSeries is composed of the SubSeries listed below.

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