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Maternal Vitamin C regulates DNA demethylation and development of the mouse embryonic germline

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE109747 | GEO | 2019/07/01

REPOSITORIES: GEO

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Maternal Vitamin C regulates DNA demethylation and development of the mouse embryonic germline [RRBS]

Project description:Maternal Vitamin C is required in vivo for proper DNA demethylation and development of fetal germ cells in a mouse model of Vitamin C deficiency. Withdrawal of Vitamin C from the maternal diet does not affect overall embryonic development but leads to defects in the fetal germline, which persist well after Vitamin C re-supply during late gestation. The transcriptome of germ cells from Vitamin C-deficient embryos is remarkably similar to that of embryos carrying a mutation in Tet1, which is responsible for DNA demethylation and activation of regulators of meiosis. In agreement with these results, Vitamin C deficiency leads to an aberrant DNA methylation profile that includes incomplete demethylation of key regulators of meiosis and transposable elements. These findings reveal that deficiency in Vitamin C during gestation recapitulates a mutation in Tet1 and disrupts germline reprogramming and development. Our work further indicate that the embryonic germline is sensitive to perturbations of the maternal diet, providing a potential intergenerational mechanism for adjusting fecundity to environmental quality.

2019-07-01 | GSE109746 | GEO

Maternal Vitamin C regulates DNA demethylation and development of the mouse embryonic germline [RNA-Seq]

2019-07-01 | GSE109745 | GEO

Maternal Vitamin C regulates DNA demethylation and devlopment of the mouse embryonic germline [Cut&Run]

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Maternal Vitamin C regulates DNA demethylation and development of the mouse embryonic germline

Project description:Maternal Vitamin C regulates DNA demethylation and development of the mouse embryonic germline

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Maternal Vitamin C regulates DNA demethylation and devlopment of the mouse embryonic germline [soma RNA-seq]

2019-07-01 | GSE125495 | GEO

Maternal Vitamin C regulates DNA demethylation and development of the mouse embryonic germline [RRBS]

Project description:Maternal Vitamin C regulates DNA demethylation and development of the mouse embryonic germline [RRBS]

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Maternal vitamin C regulates reprogramming of DNA methylation and germline development.

Project description:Development is often assumed to be hardwired in the genome, but several lines of evidence indicate that it is susceptible to environmental modulation with potential long-term consequences, including in mammals1,2. The embryonic germline is of particular interest because of the potential for intergenerational epigenetic effects. The mammalian germline undergoes extensive DNA demethylation3-7 that occurs in large part by passive dilution of methylation over successive cell divisions, accompanied by active DNA demethylation by TET enzymes3,8-10. TET activity has been shown to be modulated by nutrients and metabolites, such as vitamin C11-15. Here we show that maternal vitamin C is required for proper DNA demethylation and the development of female fetal germ cells in a mouse model. Maternal vitamin C deficiency does not affect overall embryonic development but leads to reduced numbers of germ cells, delayed meiosis and reduced fecundity in adult offspring. The transcriptome of germ cells from vitamin-C-deficient embryos is remarkably similar to that of embryos carrying a null mutation in Tet1. Vitamin C deficiency leads to an aberrant DNA methylation profile that includes incomplete demethylation of key regulators of meiosis and transposable elements. These findings reveal that deficiency in vitamin C during gestation partially recapitulates loss of TET1, and provide a potential intergenerational mechanism for adjusting fecundity to environmental conditions.

| S-EPMC8423347 | biostudies-literature

Maternal Vitamin C regulates DNA demethylation and development of the mouse embryonic germline [RNA-Seq]

Project description:Maternal Vitamin C regulates DNA demethylation and development of the mouse embryonic germline [RNA-Seq]

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Maternal Vitamin C regulates DNA demethylation and devlopment of the mouse embryonic germline [Cut&Run]

Project description:Maternal Vitamin C regulates DNA demethylation and devlopment of the mouse embryonic germline [Cut&Run]

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Maternal Vitamin C regulates DNA demethylation and devlopment of the mouse embryonic germline [soma RNA-seq]

Project description:Maternal Vitamin C regulates DNA demethylation and devlopment of the mouse embryonic germline [soma RNA-seq]

| PRJNA516595 | ENA