Genomics

Dataset Information

0

Binding of the pioneer factor FOXA1 is independent of hormonal signalling


ABSTRACT: We hormone deprived MCF-7 and ZR75-1 breast cancer cells for three days and treated them with vehicle (ethanol) or estrogen for 45 minutes. We then performed FOXA1 ChIP-seq and showed that the vast majority (>99%) of FOXA1 binding events are not affected by steroid conditions. A small number (<1%) of FOXA1 binding sites appear to be induced by estrogen, but these are not genuine de novo binding sites and represent ‘shadow’ binding sites that result from chromatin interactions at super-enhancer containing estrogen-regulated genomic regions. FOXA1 is therefore not regulated by estrogen and remains a bone fide therapeutic target that is entirely upstream of the ER complex.

ORGANISM(S): Homo sapiens

PROVIDER: GSE112969 | GEO | 2019/03/07

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2016-06-08 | PXD004271 | Pride
2016-01-11 | E-GEOD-69043 | biostudies-arrayexpress
2023-05-21 | GSE175418 | GEO
| PRJNA449633 | ENA
2023-05-21 | GSE175401 | GEO
2011-09-05 | E-GEOD-29073 | biostudies-arrayexpress
2016-08-01 | E-GEOD-72690 | biostudies-arrayexpress
2010-11-17 | E-GEOD-25314 | biostudies-arrayexpress
2022-05-27 | GSE204726 | GEO
2022-12-11 | GSE55680 | GEO