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RNAi-dependent epimutation induces broad antifungal resistance in Mucor circinelloides

ABSTRACT: To elucidate the role of epimutation in antifungal resistance of Mucor, epimutations were isolated that confer resistance to 5-fluoroorotic acid (5-FOA). We identified epimutant strains that exhibit resistance to 5-FOA without mutations in either of the 5-FOA target genes, pyrF or pyrG. Using sRNA sequencing, we demonstrate that these epimutants harbor sRNA against either pyrF or pyrG, and further show that this sRNA is lost after reversion to drug sensitivity.

ORGANISM(S): Mucor circinelloides

PROVIDER: GSE113706 | GEO | 2019/01/16

REPOSITORIES: GEO

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RNAi-dependent epimutation induces broad antifungal resistance in Mucor circinelloides

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