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Role of NEDD4 E3s in CD4+ T cell activation

ABSTRACT: Itch and WWP2 belongs to NEDD4 E3 family, and highly share the structural homology. However it remains elusive whether there are redundant or distinct roles in helper CD4+ T cell differentiation. Here we performed RNA seq analysis using WT, single and double knockout CD4+ T cells, and demonstrated the cooperative effect of the two E3s on Th2 differentiation.

ORGANISM(S): Mus musculus

PROVIDER: GSE114021 | GEO | 2018/05/24

REPOSITORIES: GEO

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