Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Spleen, T Cell, Lymph Node
SUBMITTER: Hossein Fazelinia
LAB HEAD: Steven H. Seeholzer
PROVIDER: PXD019272 | Pride | 2021-01-07
REPOSITORIES: Pride
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q180808_PO1310_DIA_0_16.raw | Raw |
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European journal of immunology 20200609 10
To mount an antipathogen response, CD4 T cells must undergo rapid cell proliferation; however, poorly controlled expansion can result in diseases such as autoimmunity. One important regulator of T-cell activity is the E3 ubiquitin ligase Itch. Itch deficient patients suffer from extensive autoinflammation. Similarly, Itch deficient mice exhibit inflammation characterized by high numbers of activated CD4 T cells. While the role of Itch in limiting CD4 T-cell cytokine production has been extensive ...[more]