Transcriptomics

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Protective role of oleic acid in angiotensin II-induced cardiac remodeling


ABSTRACT: To gain mechanistic insights into the protective effects of oleic acid (OA) on angiotensin II(AngII)-induced cardiac remodeling, a whole transcriptomic analysis of heart were performed using RNA-seq.Comparing with heart of normal mice, a total of 1468 genes (987 upregulated and 481 down regulated) were differentially expressed (FDR<0.05) in heart of AngII-induced mice. Comparing with heart of AngII-induced mice, a total of 785 genes (162 upregulated and 623 down regulated) were differentially expressed (FDR<0.05) in heart of OA treated mice. Importantly, among the 987 upregulated genes in heart of AngII-induced mice,388 genes were significantly reversed in heart of OA treated mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE114116 | GEO | 2018/05/08

REPOSITORIES: GEO

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