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SWI/SNF remains localized to chromatin in the presence of SCHLAP1 (ATAC-seq)

ABSTRACT: Changes to chromatin openness were measured by ATAC seq in RWPE1 cells expression SCHLAP1 or a control cell line infected with a LACZ lentivirus.

ORGANISM(S): Homo sapiens

PROVIDER: GSE114391 | GEO | 2018/05/14

REPOSITORIES: GEO

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SWI/SNF remains localized to chromatin in the presence of SCHLAP1 (ChIP-seq)

Project description:ChIP-seq of SWI/SNF subunits and histone modifications in RWPE1 cells

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SWI/SNF remains localized to chromatin in the presence of SCHLAP1.

Project description:SCHLAP1 is a long noncoding RNA that is reported to function by depleting the SWI/SNF complex from the genome. We investigated the hypothesis that SCHLAP1 affects only specific compositions of SWI/SNF. Using several assays, we found that SWI/SNF is not depleted from the genome by SCHLAP1 and that SWI/SNF is associated with many coding and noncoding RNAs, suggesting that SCHLAP1 may function in a SWI/SNF-independent manner.

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SWI/SNF remains localized to chromatin in the presence of SCHLAP1

Project description:This SuperSeries is composed of the SubSeries listed below.

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SWI/SNF remains localized to chromatin in the presence of SCHLAP1 (RIP-seq)

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SWI/SNF remains localized to chromatin in the presence of SCHLAP1

Project description:SWI/SNF remains localized to chromatin in the presence of SCHLAP1

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SWI/SNF remains localized to chromatin in the presence of SCHLAP1 (ChIP-seq)

Project description:SWI/SNF remains localized to chromatin in the presence of SCHLAP1 (ChIP-seq)

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SWI/SNF remains localized to chromatin in the presence of SCHLAP1 (RIP-seq)

Project description:SWI/SNF remains localized to chromatin in the presence of SCHLAP1 (RIP-seq)

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SWI/SNF remains localized to chromatin in the presence of SCHLAP1 (ATAC-seq)

Project description:SWI/SNF remains localized to chromatin in the presence of SCHLAP1 (ATAC-seq)

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The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex.

Project description:Prostate cancers remain indolent in the majority of individuals but behave aggressively in a minority. The molecular basis for this clinical heterogeneity remains incompletely understood. Here we characterize a long noncoding RNA termed SChLAP1 (second chromosome locus associated with prostate-1; also called LINC00913) that is overexpressed in a subset of prostate cancers. SChLAP1 levels independently predict poor outcomes, including metastasis and prostate cancer-specific mortality. In vitro and in vivo gain-of-function and loss-of-function experiments indicate that SChLAP1 is critical for cancer cell invasiveness and metastasis. Mechanistically, SChLAP1 antagonizes the genome-wide localization and regulatory functions of the SWI/SNF chromatin-modifying complex. These results suggest that SChLAP1 contributes to the development of lethal cancer at least in part by antagonizing the tumor-suppressive functions of the SWI/SNF complex.

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Mitotic bookmarking by SWI/SNF subunits.

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