Genomics

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Absolute quantification of proteins and histone modifications in Drosophila embryos reveals stoichiometric relationships in chromatin regulation


ABSTRACT: High-level H3K27me3 domains are required for proper gene repression mediated by Polycomb proteins. Genome-wide profiling of H3K27 methylation during developmental progression and in animals with reduced PRC2 levels illustrates how mass spectrometry-based normalization permits the quantitative analysis of changes in chromatin states.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE114832 | GEO | 2019/10/18

REPOSITORIES: GEO

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