Absolute quantification of proteins and histone modifications in Drosophila embryos reveals stoichiometric relationships in chromatin regulation
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ABSTRACT: High-level H3K27me3 domains are required for proper gene repression mediated by Polycomb proteins. Genome-wide profiling of H3K27 methylation during developmental progression and in animals with reduced PRC2 levels illustrates how mass spectrometry-based normalization permits the quantitative analysis of changes in chromatin states.
ORGANISM(S): Drosophila melanogaster
PROVIDER: GSE114832 | GEO | 2019/10/18
REPOSITORIES: GEO
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