Other

Dataset Information

0

Identification of novel ETn insertions in KRAB-ZFP cluster depleted mice


ABSTRACT: Genetic deletion of a large KRAB-ZFP gene cluster on chromosome 4 (Chr4-cl) leads to transcriptional reactivation of retrotransposons (mainly ETn elements) in ES cells. We therefore wanted to test whether ETn elements retrotranspose in Chr4-cl KO mice at higher frequency. For this we purified genomic DNA from WT and KO mice, enriched gDNA libraries using ETn capture probes and sequenced those libraries as paire-end reads. These reads were then used to identify novel ETn insertions that are not annotated in the reference genome or present in the germ line of their progenitors.

ORGANISM(S): Mus musculus

PROVIDER: GSE115285 | GEO | 2019/06/27

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2019-06-27 | GSE115286 | GEO
2019-06-27 | GSE115289 | GEO
| PRJNA474487 | ENA
2016-03-15 | E-GEOD-74278 | biostudies-arrayexpress
2019-06-27 | GSE115288 | GEO
2016-03-15 | GSE74278 | GEO
| PRJNA474491 | ENA
2019-06-27 | GSE115287 | GEO
2013-07-05 | E-GEOD-47132 | biostudies-arrayexpress
| S-EPMC4896391 | biostudies-literature