Transcriptomics

Dataset Information

0

Displacement of WDR5 from chromatin by a pharmacological WIN site inhibitor with picomolar affinity


ABSTRACT: We discovered potent small molecule inhibitors against the WIN site of WDR5. These inhibitors selectively block the proliferation of mammalian cells carrying fusions of the MLL1 oncogene. Here, we show that these inhibitors result in the rapid displacement of WDR5 from chromatin in both sensitive (MV4:11) and non-sensitive (K562) cell lines, induce early changes in the distribution of active polymerases at a subset of WDR5-bound genes, and induce global transcript changes that are consistent with induction of the tumor suppressor p53.

ORGANISM(S): Homo sapiens

PROVIDER: GSE115377 | GEO | 2019/03/12

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2021-01-19 | GSE150400 | GEO
2022-02-03 | GSE183781 | GEO
2021-01-25 | PXD019209 | Pride
| PRJNA631994 | ENA
| PRJNA474736 | ENA
2020-01-17 | GSE136451 | GEO
2023-07-04 | PXD035129 | Pride
2022-01-27 | PXD025257 | Pride
2022-03-03 | GSE173207 | GEO
2022-03-03 | GSE189205 | GEO