Collateral Flow Evokes Distinct Endothelial Gene Expression
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ABSTRACT: Biomechanical forces influence vascular function, but the molecular mechanisms regulating many of these mechano-activated cellular events remain largely uncharacterized. In particular, the vascular endothelium can sense alterations in hemodynamic shear stress which, in the context of adaptive remodeling or arteriogenesis, has been shown to lead to the generation of endothelial-derived signals critical for controlling blood vessel structure and function. Here, we sought to define the arteriogenic responses evoked in endothelial cells exposed to flow using transciptional profiling. Analysis of these transcriptional programs identified several genes previously shown to be important for endothelial-smooth muscle interactions and vascular remodeling, including the transcription factor kruppel-like factor 2 (KLF2).
ORGANISM(S): Homo sapiens
PROVIDER: GSE11583 | GEO | 2009/01/01
SECONDARY ACCESSION(S): PRJNA106215
REPOSITORIES: GEO
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