Transcriptomics

Dataset Information

0

Rescue of alpha-synuclein toxicity in a yeast model of Parkinson's disease


ABSTRACT: Cellular toxicities of alpha-synuclein manifest through multiple pathways, including mitochondrial dysfunction and the inhibition of vesicle trafficking. Several defects can be ameliorated by small molecule suppressors that antagonize toxicity in model systems ranging from yeast to neurons. Connections between these distinct pathologies may be central to Parkinson Disease and to therapeutic strategies. First, yeast cultures with 1 or 2 copies of human alpha-synuclein were profiled during a time series of 0 to 6 hours. Second, to investigate any potential rescue of alpha-synuclein toxicity, one of a series of six compounds: compound 1 ((4-(3-iodophenyl)-3,4-dihydrobenzo[h]quinolin-2(1H)-one); compound 2 (4-(3-bromophenyl)-3,4-dihydrobenzo[h]quinolin-2(1H)-one); compound 3 (4-(5-bromo-2-fluorophenyl)-6,7-dimethyl-3,4-dihydro-2(1H)-quinolinone); compound 4 (4-(3-bromo-4-fluorophenyl)-6,7-dimethyl-3,4-dihydro-2(1H)-quinolinone); compound 5 (4-(4-ethyl)-6,7-dimethyl-3,4-dihydro-2(1H)-quinolinone); compound 6 ((4R)-6-bromo-4-(4-ethylphenyl)-3,4-dihydrobenzo[h]quinolin-2(1H)-one); was introduced and the expression profile assayed at 4 hours.

ORGANISM(S): Saccharomyces cerevisiae

PROVIDER: GSE11633 | GEO | 2010/01/04

SECONDARY ACCESSION(S): PRJNA106153

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2020-12-12 | GSE163046 | GEO
2022-08-30 | GSE145482 | GEO
2024-05-21 | GSE240854 | GEO
| PRJNA515038 | ENA
2015-04-28 | E-GEOD-68026 | biostudies-arrayexpress
2021-09-28 | GSE166127 | GEO
2011-09-14 | E-GEOD-30792 | biostudies-arrayexpress
2011-09-14 | E-GEOD-28365 | biostudies-arrayexpress
2020-09-02 | GSE149632 | GEO
2013-10-28 | E-GEOD-51781 | biostudies-arrayexpress