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Identification and validation of a tumor-infiltrating Treg transcriptional signature conserved across species and tumor types.

ABSTRACT: We reported transcriptional characterization of tumor-infiltrating T regulatory cells (TITRs) that is shared between species and among different tumor types and stages. We genomically profiled immunocytes from 2 species: 1. Mouse: CD4+ Treg and Tconv, and CD8+ T cells from tumor and spleen of B16, MC38 or CT26 tumor bearing mice, as well as from spleens of non-tumor bearing mice. 2. Human: CD4+ Treg cells from surgically resected and cryopreserved human colorectal carcinomas or normal colon tissue.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE116347 | GEO | 2018/12/21

REPOSITORIES: GEO

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