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Effect of glutathione reductase (Gsr) deficiency on lung transcriptomics in embryonic mice and neonatal and adult mice exposed to hyperoxia.

ABSTRACT: Gsr is an antioxidant enzyme responsible for maintaining the supply of reduced glutathiones which reduce reactive oxigen species and maintain cellular redox balance. However, the the role for Gsr in the developemnt of oxidative lung injury is not well characterized. We used microarray analysis to identify Gsr-dependent genes and pathways in embyronic, neonate, and adult lungs. We also determined Gsr-dependent lung transcriptomics in mouse neonates and adults which were neonatally exposed to hyperoxia (O2) or air.

ORGANISM(S): Mus musculus

PROVIDER: GSE116485 | GEO | 2020/12/09

REPOSITORIES: GEO

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