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The long non-coding RNA landscape of periodontal ligament stem cells subjected to compressive force

ABSTRACT: To explore the lncRNA landscape of periodontal ligament stem cells (PDLSCs) subjected to compressive force.

ORGANISM(S): Homo sapiens

PROVIDER: GSE116787 | GEO | 2021/07/09

REPOSITORIES: GEO

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Differential gene expression of static and intermittent compressive force treated human periodontal ligament cells

Project description:Mechanical force has been shown to regulate periodontal ligament cells (PDLs) behaviors. However, different force types lead to distinct PDLs’ responses. Here, the differential gene expression profiling of PDLs subjected to static and intermittent compressive forces was examined using RNA sequencing technique. Results demonstrated that the static and intermittent compressive force treated PDLs exhibited the differential regulation genes. KEGG pathway enrichment analysis revealed that focal adhesion and transforming growth factor beta signaling pathway were commonly upregulated while calcium signaling pathway was downregulated in both static and intermittent compressive force-treated PDLs. Interestingly, Wnt signaling pathway was upregulated only in the PDLs that subjected to the intermittent compressive force.

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The long non-coding RNA landscape of periodontal ligament stem cells subjected to compressive force

Project description:The long non-coding RNA landscape of periodontal ligament stem cells subjected to compressive force

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Differential gene expression of static and intermittent compressive force treated human periodontal ligament cells

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Transcriptional Expression in Human Periodontal Ligament Cells Subjected to Orthodontic Force: An RNA-Sequencing Study

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Expression data from human periodontal ligament

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