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Fucntional genetic variants mediate their regulatory effects through altered transcription factor binding. [dirRNA-seq]

ABSTRACT: The extensive molecular characterization of the transcriptional regulatory landscape within the LCLs of a 3-generation, 17-member kindred was performed to allow for the identification of functional variants. A variant associated with changes in multiple molecular phenotypes was selected for validation through precise CRISPR/Cas9 editing. Edited clones were subsequently tested for reconstitution of function through CRISPR/dCas9 targeted TF activation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE117484 | GEO | 2019/06/04

REPOSITORIES: GEO

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