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Fucntional genetic variants mediate their regulatory effects through altered transcription factor binding. [dirRNA-seq]

ABSTRACT: Fucntional genetic variants mediate their regulatory effects through altered transcription factor binding. [dirRNA-seq]

PROVIDER: PRJNA482546 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7586270_1.fastq.gz	Fastqsanger.gz
	SRR7586270_2.fastq.gz	Fastqsanger.gz
	SRR7586280_1.fastq.gz	Fastqsanger.gz
	SRR7586280_2.fastq.gz	Fastqsanger.gz
	SRR7586290_1.fastq.gz	Fastqsanger.gz

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Project description:The extensive molecular characterization of the transcriptional regulatory landscape within the LCLs of a 3-generation, 17-member kindred was performed to allow for the identification of functional variants. A variant associated with changes in multiple molecular phenotypes was selected for validation through precise CRISPR/Cas9 editing. Edited clones were subsequently tested for reconstitution of function through CRISPR/dCas9 targeted TF activation.

2019-06-04 | GSE117574 | GEO