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Protein Syndesmos is a novel RNA binding protein that regulates primary cilia formation [Illumina array]

ABSTRACT: We show here that SDOS interacts with another important cancer-linked protein, the chaperone TRAP1, associates with actively translating polyribosomes and represses translation. Moreover, we demonstrate that SDOS binds directly RNA in living cells. Combining individual gene expression profiling, nucleotide cross-linking and immunoprecipitation (iCLIP), and ribosome profiling, we discover several crucial pathways regulated post-transcriptionally by SDOS.

ORGANISM(S): Homo sapiens

PROVIDER: GSE118035 | GEO | 2018/09/26

REPOSITORIES: GEO

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Protein Syndesmos is a novel RNA binding protein that regulates primary cilia formation [iCLIP-seq]

Project description:We show here that SDOS interacts with another important cancer-linked protein, the chaperone TRAP1, associates with actively translating polyribosomes and represses translation. Moreover, we demonstrate that SDOS binds directly RNA in living cells. Combining individual gene expression profiling, nucleotide cross-linking and immunoprecipitation (iCLIP), and ribosome profiling, we discover several crucial pathways regulated post-transcriptionally by SDOS.

2018-09-26 | GSE118049 | GEO

Protein Syndesmos is a novel RNA binding protein that regulates primary cilia formation [Ribo-seq]

Project description:We show here that NUDT16L1/TIRR/Syndesmos (SDOS) interacts with another important cancer-linked protein, the chaperone TRAP1, associates with actively translating polyribosomes and represses translation. Moreover, we demonstrate that SDOS binds directly RNA in living cells. Combining individual gene expression profiling, nucleotide cross-linking and immunoprecipitation (iCLIP), and ribosome profiling, we discover several crucial pathways regulated post-transcriptionally by SDOS.

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Coordinated regulation of protein synthesis and mitochondrial respiration by the molecular chaperone TRAP1 in cancer cells

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The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in maintaining mitochondrial metabolic homeostasis

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functional targets of cilia dependent cyst activation (CDCA) and a potential therapeutic targets for treating polycystic kidney disease

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