Canine pimary osteosarcoma tissues vs. matched lung metastases
Ontology highlight
ABSTRACT: Osteosarcomas (OS) have highly chaotic genomes, yet their cancer drivers are poorly defined. Given that cancer genes are conserved among mammals, cross-species genomics of naturally arising cancers opens a powerful approach to identifying oncogenic drivers to broaden the therapeutic opportunities for aggressive cancers. Here, we utilized a dog-to-human cross-species genomics combined with gain- and loss-of-function analysis to uncover novel OS driver genes.
ORGANISM(S): Canis lupus familiaris
PROVIDER: GSE118130 | GEO | 2021/08/03
REPOSITORIES: GEO
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