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Expression array of carcinoma cell Mmp14-targeted MMTV-PyMT mammary tumors

ABSTRACT: Breast carcinoma cell invasion is thought to depend on the mobilization of the membrane-anchored matrix metalloproteinase, Mmp14/MT1-MMP, to drive the remodeling of extracellular matrix and trigger associated signaling cascades. However, the roles that this proteinase plays during breast tumor progression and invasion in vivo remain undefined. A highly penetrant syngeneic mouse model for luminal B breast cancer driven by the polyoma middle T (PyMT) antigen, in tandem with recently developed Mmp14-floxed mice and MMTV-Cre transgenics that express Cre recombinase throughout the mammary epithelial cell compartment, were used to characterize the impact of conditional Mmp14-targeting on breast carcinoma cell invasion programs in vivo. Transcriptome profiling of intact MMTV-PyMT carcinoma tumors was used to investigate the functional roles of carcinoma cell-derived MT1-MMP in MMTV-PyMT tumor progression and invasion in an unbiased fashion

ORGANISM(S): Mus musculus

PROVIDER: GSE118466 | GEO | 2018/12/01

REPOSITORIES: GEO

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Expression array of mammary epithelial cells isolated from epithelial Mmp14-targeted mammary glands

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Expression array of carcinoma cell Mmp14-targeted MMTV-PyMT mammary tumors

Project description:Expression array of carcinoma cell Mmp14-targeted MMTV-PyMT mammary tumors

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