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LXR-dependent gene expression in mouse bone marrow derived macrophages

ABSTRACT: Bone marrow derived macrophages were isolated from C57BL/6J (LXR positive) and LXRalpha +LXRbeta double knockout mice (DKO) that had been treated with vehicle, Kado2-lipid A (KLA, and inflammatory stimulus), acetylated LDL (AcLDL, a mimic of pro-atherogenic lipoprotein particles) and GW3965 (GW, a synthetic LXR agonist) for 17 hours. Following treatment RNA was isolated and RNA-Seq was performed.

ORGANISM(S): Mus musculus

PROVIDER: GSE118656 | GEO | 2018/08/17

REPOSITORIES: GEO

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