Unknown,Transcriptomics,Genomics,Proteomics

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LXR activation in RAW264.7 mouse macrophages expressing LXRalpha.

ABSTRACT: To identify novel LXR target genes, we conducted transcriptional profiling studies using RAW264.7 cells ectopically expressing LXRalpha Total RNA was isolated from RAW264.7 macrophages ectopically expressing LXRalpha as described in Venkateswaran et al. (2000); PNAS 97, 12097-12102. Cells were cultured with DMSO or GW3965 (1 μM) and LG268 (100 nM). Transcriptional profiling was performed at the UCLA microarray core facility using murine Affymetrix 430 2.0 microarrays.

ORGANISM(S): Mus musculus

SUBMITTER: ANTONIO CASTRILLO 

PROVIDER: E-GEOD-17088 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Effective clearance of apoptotic cells by macrophages is essential for immune homeostasis. The transcriptional pathways that allow macrophages to sense and respond to apoptotic cells are poorly defined. We found that liver X receptor (LXR) signaling was important for both apoptotic cell clearance and the maintenance of immune tolerance. Apoptotic cell engulfment activated LXR and thereby induced the expression of Mer, a receptor tyrosine kinase critical for phagocytosis. LXR-deficient macrophage  ...[more]

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