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IL-6 overexpression-associated gene expression in cholangiocarcinoma cells

ABSTRACT: The association between chronic inflammation and the development and progression of malignancy is exemplified in the biliary tract where persistent inflammation strongly predisposes to cholangiocarcinoma. The inflammatory cytokine interleukin-6 (IL-6) enhances tumor growth in cholangiocarcinoma by altered gene expression via autocrine mechanisms. We therefore investigated the effect of chronic exposure to IL-6 on gene expression using malignant cholangiocytes stably transfected to overexpress IL-6. Comparison of gene expression identified several genes that were altered by enforced IL-6 expression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE11883 | GEO | 2008/06/26

SECONDARY ACCESSION(S): PRJNA105701

REPOSITORIES: GEO

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