Transcriptomics

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RNA sequencing of FHR1-treated human monocytes


ABSTRACT: The plasma protein FHR1 induces release of inflammatory cytokines IL-1β, IL-6, IL-18 or TNFα from blood-derived human monocytes. RNA sequencing was performed from RNA of BSA- or FHR1-treated monocytes from 4 different donors. In response to FHR1, 522 monocytic genes were upregulated (gene ontology enrichment analysis), including 35 inflammation related genes, e.g. TNF. Also, G protein-coupled receptors such as EMR2/ADGRE2 were upregulated in response to FHR1.

ORGANISM(S): Homo sapiens

PROVIDER: GSE119025 | GEO | 2018/08/25

REPOSITORIES: GEO

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