Transcriptomics

Dataset Information

0

Plucked hair follicles from patients with chronic discoid lupus erythematosus show a disease-specific molecular signature


ABSTRACT: When faced with clinical symptoms of scarring alopecia – the standard diagnostic pathway involves a scalp biopsy which is an invasive and expensive procedure. Furthermore, clinical activity of scarring alopecias is often difficult to assess as symptoms of permanent damage and signs of activity can overlap or be difficult to distinguish. Here we report that gene expression analysis of only a small number of hair follicles (HF) plucked from lesional areas of the scalp is sufficient to characterise chronic discoid lupus erythematosus (CDLE). Lesional and non-lesional HFs were extracted from the scalp of patients with CDLE, psoriasis and healthy controls. The expression profile from CDLE HFs coincides with published profiles of CDLE from skin biopsy and was consistent with histopathological diagnostic features of CDLE. We therefore propose that information obtained from this non-invasive approach are sufficient to diagnose scalp LE.

ORGANISM(S): Homo sapiens

PROVIDER: GSE119207 | GEO | 2018/10/31

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2024-04-10 | GSE206790 | GEO
2022-01-25 | GSE148346 | GEO
2015-11-25 | E-GEOD-75343 | biostudies-arrayexpress
2021-09-15 | GSE179054 | GEO
2017-02-24 | E-MTAB-5542 | biostudies-arrayexpress
2021-03-22 | GSE113052 | GEO
2008-10-19 | GSE12689 | GEO
2024-08-22 | PXD050245 | Pride
2013-07-04 | E-MEXP-3859 | biostudies-arrayexpress
2020-10-31 | GSE160501 | GEO