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Genome-wide characterization of REST binding regions in LNCaP prostate cancer cells

ABSTRACT: Transcriptional regulator REST plays a key role in repressing neuronal specific genes in prostate cancer and other non-neuronal tissues. Moreover, loss of REST is observed in neuroendocrine prostate tumors. Here, we use ChIP-seq analysis to study genome–wide REST occupied regions in the prostate cancer cell line, LNCaP. REST occupied regions were then correlated to gene expression changes occurring between prostate adenocarcinoma and neuroendocrine prostate tumors in vivo.

ORGANISM(S): Homo sapiens

PROVIDER: GSE119385 | GEO | 2019/09/03

REPOSITORIES: GEO

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