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Regulation of TLR8-activated gene expression in human neutrophils [RNA-seq neutrophils & monocytes]

ABSTRACT: The transcription factors that regulate gene expression in stimulated neutrophils are poorly characterized. Herein, we found that the genomic distribution of the myeloid lineage determining transcription factors PU.1 and C/EBPβ, as well as that of the histone modification H3K27Ac, which marks active chromatin, significantly change in human neutrophils treated with R848, a ligand of TLR8.

ORGANISM(S): Homo sapiens

PROVIDER: GSE119394 | GEO | 2021/05/07

REPOSITORIES: GEO

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