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Hif-1alpha deletion leads to adverse treatment efficacy in a mouse model of MLL-AF9 driven AML

ABSTRACT: This report explores the effect of Hif-1alpha deletion, using a conditional mouse model, together with standard chemotherapy regimen to evaluate leukemia stem cell (LSC) targeting in a murine model of MLL-AF9 driven acute myeloid leukemia (AML). This study reveals that Hif-1alpha-deleted leukemias displayed a faster disease progression after chemotherapy.

ORGANISM(S): Mus musculus

PROVIDER: GSE119484 | GEO | 2019/01/23

REPOSITORIES: GEO

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