Transcriptomics

Dataset Information

0

Supraphysiological Androgens Repress Prostate Cancer Growth and Induce DNA Damage Augmented by PARP Inhibition


ABSTRACT: Prostate cancer (PC) is initially dependent on androgen receptor (AR) signaling for survival and growth. Therapeutics designed to repress AR activity, such as those reducing circulating androgen levels, serve as the primary intervention for advanced disease. However, supraphysiological androgen (SPA) concentrations, can produce a paradoxical response leading to growth inhibition. We sought to determine the mechanisms by which SPA represses PC growth and determine if molecular context associates with anti-tumor effects.

ORGANISM(S): Homo sapiens

PROVIDER: GSE119598 | GEO | 2019/07/09

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2023-05-26 | GSE228896 | GEO
2023-05-26 | GSE228895 | GEO
2023-05-26 | GSE225481 | GEO
2022-11-01 | GSE213443 | GEO
2022-11-01 | GSE213437 | GEO
2023-04-12 | GSE229555 | GEO
| PRJNA489692 | ENA
2013-05-02 | E-GEOD-34589 | biostudies-arrayexpress
2015-01-21 | E-GEOD-63539 | biostudies-arrayexpress
2024-06-21 | GSE262117 | GEO